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Words near each other
・ Interleukin 10
・ Interleukin 10 receptor, alpha subunit
・ Interleukin 10 receptor, beta subunit
・ Interleukin 11
・ Interleukin 11 receptor alpha subunit
・ Interleukin 12
・ Interleukin 12 receptor, beta 1 subunit
・ Interleukin 12 receptor, beta 2 subunit
・ Interleukin 12 subunit beta
・ Interleukin 13
・ Interleukin 13 receptor, alpha 1
・ Interleukin 15
・ Interleukin 15 receptor, alpha subunit
・ Interleukin 16
・ Interleukin 17
Interleukin 18
・ Interleukin 19
・ Interleukin 2
・ Interleukin 20
・ Interleukin 20 receptor, alpha subunit
・ Interleukin 20 receptor, beta subunit
・ Interleukin 21
・ Interleukin 22
・ Interleukin 23
・ Interleukin 23 subunit alpha
・ Interleukin 24
・ Interleukin 25
・ Interleukin 26
・ Interleukin 27
・ Interleukin 27 receptor, alpha subunit


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Interleukin 18 : ウィキペディア英語版
Interleukin 18

Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the ''IL18'' gene. The protein encoded by this gene is a proinflammatory cytokine.
== Function ==

IL-18 is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3606 )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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